EU HBM framework

The ‘protocol team’ developed a common European protocol in close collaboration with 17 countries taking part in a demonstration study (see DEMOCOPHES). Six COPHES groups worked together on guidelines for population sampling, recruitment and biological sample collection; biological sample handling, analysis and biobanking; data analysis and integrated interpretation; communication and dissemination; and training and capacity building.

After gathering all possible information on existing experience and expertise (via an EU questionnaire and personal contacts), a working version of the common protocol was finalized on 3rd March 2011.

The common protocol guided the development of national protocols in 17 European countries, assessing exposure of (around) 1800 children and their mothers to cadmium, cotinine, mercury and phthalates. A few countries addressed other pollutants in addition, such as Bisphenol A, Triclosan and Parabene.

The protocol team supports the implementation of the pilot survey study through a helpdesk and through training activities. It also provides support for the ethical and legal aspects (see under Ethics).

Due to the differences in policy, culture and ethics from one country to another, a one-size-fits-all scheme of mandatory operational procedures for all participating countries was not an option.  The individual participating countries adapted certain study elements to the country's realities in order to maximise the use of existing resources. Information on these differences will help elaborating recommendations for further steps and more advanced guidelines.

Regular reporting is done at the COPHES and DEMOCOPHES meetings. The finalized material will be presented at the final meeting in Cyprus and added to this website.